Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an <i>In Vitro</i> Pharmacokinetic/Pharmacodynamic Model

Abstract

This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) <i>in vitro</i> in 24-h time-kill settings and in <i>ex vivo</i> simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infections.