The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response - Concepedia

Concepedia

Publication | Open Access

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

DOI Full Paper Access

58

Citations

56

References

2020

Year

Shinrye Lee, Seyeon Kim, Ha‐Young Kang, Hye Ryeong Lim, Younghwi Kwon, Myungjin Jo, Yu‐Mi Jeon, Sang Ryong Kim, Kiyoung Kim, Chang Man Ha,

Journal of Neuroinflammation

Abstract

These results indicate that PTP1B inhibition mitigates the neuronal toxicity caused by TDP-43-induced inflammation in mammalian astrocytes and Drosophila glial cells.

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