Concepedia

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

Shinrye Lee, Seyeon Kim, Ha‐Young Kang, Hye Ryeong Lim, Younghwi Kwon, Myungjin Jo, Yu‐Mi Jeon, Sang Ryong Kim, Kiyoung Kim, Chang Man Ha,

Journal of Neuroinflammation · 2020 · 58 citations · 56 references

DOIFull text

Open access

Abstract

These results indicate that PTP1B inhibition mitigates the neuronal toxicity caused by TDP-43-induced inflammation in mammalian astrocytes and Drosophila glial cells.

References

56

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed · 1997 · 66.5K citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Elisabetta Polazzi, Ilaria Mengoni, Marco Caprini et al. · Neurosignals · 2012 · 9K citations · Full text

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Manuela Neumann, Deepak M. Sampathu, Linda K. Kwong et al. · Science · 2006 · 6.5K citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

Ken D. McCarthy, Jean de Vellis · The Journal of Cell Biology · 1980 · 3.9K citations · Full text

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