Evidences of CTLA-4 and PD-1 Blocking Agents-Induced Cardiotoxicity in Cellular and Preclinical Models - Concepedia

Concepedia

Publication | Open Access

Evidences of CTLA-4 and PD-1 Blocking Agents-Induced Cardiotoxicity in Cellular and Preclinical Models

DOI Full Paper Access

64

Citations

45

References

2020

Year

Vincenzo Quagliariello, Margherita Passariello, Domenica Rea, Antônio Barbieri, Martina Iovine, Annamaria Bonelli, Antonietta Caronna, Gerardo Botti, Claudia De Lorenzo, Nicola Maurea

Journal of Personalized Medicine

Abstract

Nivolumab and Ipilimumab exert cytotoxic effects mediated by the NLRP3/IL-1β and MyD88 pathways, leading to pro-inflammatory cytokine storm in heart tissue.

References

	Year	Citations

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