Concepedia

Meeting key synthetic challenges in amanitin synthesis with a new cytotoxic analog: 5′-hydroxy-6′-deoxy-amanitin

Alla Pryyma, Kaveh Matinkhoo, Antonio A. W. L. Wong, David M. Perrin

Chemical Science · 2020 · 11 citations · 42 references

DOIFull text

Open access

Concepts

Abstract

Elucidating a highly diastereoselective sulfoxidation of<italic>S</italic>-deoxy-amanitin to afford α-amanitin and a more synthetically accessible analog of near-native toxicity.

References

42

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Oleg Trott, Arthur J. Olson · Journal of Computational Chemistry · 2009 · 37.1K citations · Full text

, , +17

The PyMOL Molecular Graphics System

Warren L. DeLano · Medical Entomology and Zoology · 2002 · 18.1K citations

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Ligand docking and binding site analysis with PyMOL and Autodock/Vina

Daniel Seeliger, Bert L. de Groot · Journal of Computer-Aided Molecular Design · 2010 · 2.6K citations · Full text

, , +14

Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin

Thomas J. Lindell, Fanyela Weinberg, Paul W. Morris et al. · Science · 1970 · 868 citations

, , +13

Synthesis of Chiral Sulfoxides by Metal-Catalyzed Oxidation with<i>t</i>-Butyl Hydroperoxide

Fulvio Di Furia, Giorgio Modena, Roberta Seraglia · Synthesis · 1984 · 314 citations

, , +6