Antimicrobial Agents and Chemotherapy · 2020 · 53 citations · 39 references
PharmacyPharmacokineticsPharmacologyDrug DeliveryPharmacodynamicsPulmonary Drug DeliveryAntibacterial PharmacologyAntimicrobial DosingAntimicrobial PharmacodynamicsInhalation Drug DeliveryPharmacokinetics Of AntimicrobialsPulmonary PharmacokineticsAntimicrobial Dosing OptimizationBacteriophage TherapyDrug Dosing OptimizationInhaled Antibiotic AdministrationInhaled Drug PharmacokineticsOptimal Dosing Regimen DesignPseudomonas Aeruginosa ResistanceTime-kill Assays
in the lungs at 16 h. Furthermore, bacterial growth was suppressed in the PEV31-treated group, while the PBS-treated group showed exponential growth. Of the 10 colonies tested, four phage-resistant isolates were observed from the lung homogenates sampled at 24 h after phage treatment. These colonies had a different antibiogram to the parent bacteria. This study provides evidence that pulmonary delivery of phage PEV31 in mice can reduce the MDR bacterial burden.
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Passage of Inhaled Particles Into the Blood Circulation in Humans
Abderrahim Nemmar, Peter Hoet, B. Vanquickenborne et al. · Circulation · 2002 · 1.7K citations · Full text
Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa
Benjamin K. Chan, Mark Sistrom, John E. Wertz et al. · Scientific Reports · 2016 · 722 citations · Full text