Physiology Principles Underlying Goal Directed Therapies in Children

Abstract

Since the outbreak in China in December 2019 researchers searching for adequate therapy to control viral spreading and to inhibit COVID-19 effectively. To date, no effective drug to treat this severe viral infection was found. Publications about angiotensin II receptor blocker reveal a new effective method to think about in treating COVID-19 [1-5]. Moreover, different therapy options were started to stop the devastating potential of COVID-19 worldwide. Antibody-rich donated plasma from survivors, different inhibitors are part of analysis to stop the entry of the virus into the cell and disturb the connection between SARS-CoV-2 and angiotensin-2 receptor binding. Angiotensin II and the receptor play an important role in cell entry of COVID-19. For cell entry COVID-19 needs the presence of a serine protease TMPRSS2 and cathepsin L [6-9].