Molecular docking studies, anti-Alzheimer’s disease, antidiabetic, and anti-acute myeloid leukemia potentials of narcissoside

Abstract

In this research, we explored their capacity for Narcissoside antioxidant and anticholinergic, antidiabetic, and anti-acute myeloid leukaemia. Narcissoside's antioxidant activities were elucidated by the use of various bioanalytical assays. Narcissoside's radical scavenging activities were evaluated by DPPH<b>^•</b> and ABTS<b>^•</b>⁺ scavenging activities. On the other hand, IC₅₀ values were calculated for DPPH<b>^•</b>, and ABTS<b>^•</b>⁺ scavenging, acetylcholinesterase, and α-glucosidase inhibition effects of narcissoside. IC₅₀ values narcissoside, as 11.54 nM for AChE and 65.58 nM for α-glucosidase were calculated with % Activity-[Inhibitory] graphs. Then, ADME/T analysis of narcissoside molecule was performed to calculate the drug becoming parameters.