Identification of a novel tedizolid resistance mutation in <i>rpoB</i> of MRSA after <i>in vitro</i> serial passage

Abstract

To the best of our knowledge, this is the first time that an rpoB mutation has been implicated in resistance to PhLOPSa antimicrobials. The mechanism of resistance remains unclear, but is likely indirect, involving σ-factor binding or other alterations in transcriptional regulation.