ACS Applied Materials & Interfaces · 2020 · 56 citations · 57 references
Life SciencesBioengineeringImmunologyCancer ImmunologyImmunotechnologyImmunotherapyAnimal Cell CultureBiomaterials For Cell EngineeringCancer ImmunotherapyCell-based ImmunotherapyHydrogelsBiochemical CuesCell ActivationCell Culture BioprocessingHydrogels For Cell CultureImmunoengineering Of BiomaterialsSubstrate Stiffness RegulationSubstrate Stiffness TuningT Cell-based Immunotherapy
< 0.001) to enhance IL-2 secretion. Our results demonstrate the importance of physical parameters in immune cell stimulation and highlight the potential of designing future immunostimulatory biomaterials that are mechanically tailored to balance stimulatory strength and downstream proliferative capacity of therapeutic T cells.
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