Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic <i>KLF4</i> mutations predominantly in low-grade regions

Abstract

Hotspot mutations in <i>KLF4</i> occur at high prevalence in IPMNs. Unique among pancreatic driver genes, <i>KLF4</i> mutations are enriched in low-grade IPMNs. These data highlight distinct molecular features of low-grade and high-grade dysplasia and suggest diverse pathways to high-grade dysplasia via the IPMN pathway.