Concepedia

SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma

Ti‐Chun Chan, Wen‐Jeng Wu, Wei‐Ming Li, Meng‐Shin Shiao, Yow‐Ling Shiue, Chien‐Feng Li

Theranostics · 2020 · 33 citations · 32 references

DOIFull text

Open access

Concepts

Abstract

gene is a novel tumor suppressor in UCs. Total and membranous SLC14A1 prevents urea and arginine accumulation via the mTOR signaling pathway. Nuclear SLC14A1 recruits HDAC1 to transrepress oncometabolite genes.

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