Methocarbamol blocks muscular Na_v1.4 channels and decreases isometric force of mouse muscles

Abstract

The study provides evidence for peripheral actions of methocarbamol on skeletal muscle. Muscular Na⁺ channels are a molecular target of methocarbamol. Since Na_v 1.7 currents were unaffected, methocarbamol is unlikely to exert its analgesic effect by directly blocking Na_v 1.7 channels.