Bioactive compounds from <i>Physalis angulata</i> and their anti-inflammatory and cytotoxic activities

Abstract

A new compound, physalucoside A (<b>1</b>), together with seven withanolides (<b>2</b>-<b>8</b>) and three flavonoids (<b>9</b>-<b>11</b>), were isolated from <i>Physalis angulata</i> L. (Solanaceae), a medicinal plant native to Vietnam. The chemical structures of these compounds were elucidated by one- and two-dimensional NMR spectra, high-resolution electrospray ionization mass spectrometry analyses, and chemical reactivity. The anti-inflammatory and cytotoxic activities of isolated compounds were also evaluated. These data suggest that the anti-inflammatory activity of <i>P. angulata</i> is due primarily to its withanolide content. This study demonstrates the potential of withanolides as promising candidates for the development of new anti-inflammatory drugs.