Palladium‐Catalyzed Selective Carbofunctionalization of Inert γ‐C(<i>sp</i>³)−O Bonds with 4‐Hydroxypyridin‐2(<i>1H</i>)‐ones and 4‐Hydroxy‐<i>2H</i>‐pyran‐2‐ones

Abstract

Abstract The palladium‐catalyzed selective carbofunctionalization of inert γ‐C( sp 3 )−O bonds of aliphatic amides by using the strategy of sp 3 C−H activation/β‐O elimination/hydrocarbofunctionalization with the assistance of 8‐aminoquinolyl directing group is presented here. This method features a broad scope of both 4‐hydroxypyridin‐2( 1H )‐ones and 4‐hydroxy‐ 2H ‐pyran‐2‐ones, providing a versatile method for the synthesis of corresponding γ‐substituted amide derivatives. magnified image