Role of NF- B in the pathogenesis of diabetes and its associated complications

Abstract

The nuclear factorB (NFB) family is comprised of DNA-binding protein factors that are required for the transcription of most proinflammatory molecules, including adhesion molecules, enzymes, cytokines, and chemokines. Studies performed in a variety of cell and animal based experimental systems suggest that NFB activation is a key event early in the pathobiology of diabetes. The purpose of this review is to summarize the current knowledge about the molecular biology of NFB and to review evidence that implicates NFB in the pathogenesis of diabetes and its associated complications.