ACS Omega · 2020 · 21 citations · 34 references
PharmacyPharmaceuticsPharmacokineticsBioavailabilityDrug DeliveryPharmaceutical FormulationCrystallization ProcessesDrug DissolutionDrug SolubilityPhysicochemical Determinants Of BioavailabilitySolubility EnhancementSolubility OptimizationCrystal FormCrystallizationDifferential CalorimetryDrug Crystal FormForm Ii PolymorphsOral Drug BioavailabilitySolubilitySolubility Behavior
of Form II is about 2.6 times that of Form I, indicating that the solubility and bioavailability of pemafibrate can indeed be improved by forming the new polymorph Form II. It may become an ideal solid form of active pharmaceutically ingredient suitable for pharmaceutical preparations, and it can be further studied in the later period.
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Pharmaceutical Cocrystals and Their Physicochemical Properties
N. Schultheiss, Ann Newman · Crystal Growth & Design · 2009 · 1.5K citations · Full text