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Impact of <scp><i>Plasmodium vivax</i></scp> malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients

DOIFull Paper Access

12

Citations

39

References

2020

Year

Anne Cristine Gomes de Almeida, Anna Beatriz Ribeiro Elias, Maria Paula Marques, Gisely Cardoso de Melo, Allyson Guimarães Costa, Erick Frota Gomes Figueiredo, Larissa W. Brasil, Fernanda Rodrigues‐Soares, Wuelton Marcelo Monteiro, Marcus Lacerda,
British Journal of Clinical Pharmacology

Abstract

P. vivax malaria and treatment altered CYP2D6 and CYP2C19 metabolic phenotypes. CYP2C19 inhibition is attributed to a higher level of circulating proinflammatory cytokines, while suppression of CYP2D6 is ascribed mainly to chloroquine exposure.

References

YearCitations

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