Chalcogenide-Catalyzed Intermolecular Electrophilic Thio- and Halofunctionalization of <i>gem</i>-Difluoroalkenes: Construction of Diverse Difluoroalkyl Sulfides and Halides

Abstract

Thio- and halodifluoromethylated compounds are an important class of compounds in medicinal chemistry and organic synthesis. Herein, we report a facile method for the construction of these compounds via chalcogenide-catalyzed intermolecular electrophilic thio- and halofunctionalization of <i>gem</i>-difluoroalkenes. Simple treatment of <i>gem</i>-difluoroalkenes with electrophilic sulfur/halogen reagents and various <i>O</i>- or <i>N</i>-nucleophiles affords diverse multifunctionalized thio- and halodifluoromethylated compounds. This reaction features a relatively broad substrate scope, good functional group tolerance, and mild reaction conditions.