Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (<i>Caowu</i>) and Chebulae Fructus‐ (<i>Hezi</i>‐) Processed <i>Caowu</i> by UPLC‐MS/MS

Abstract

A decrease in the level of absorption and in the rate of elimination of the alkaloids can be detected when HC is administrated in the dosage form of the powder, explaining that in traditional Mongolian medicine (TMM), the purpose of using HC in the dosage forms of pills and powder is for decreasing the toxicity and prolonging the efficacy duration of HC. Decocting can greatly decrease the plasma concentration of the diester diterpenoid alkaloids in RC and increase their rate of elimination. The influence of decocting on RC is greater than that on HC, explaining the rationality of the steaming and boiling methods for processing <i>Caowu</i> and the rationality of boiling <i>Caowu</i> for a longer time beforehand in preparing an herb decoction containing <i>Caowu</i> in TCM.