Multiple cancer susceptible genes sequencing in BRCA-negative breast cancer with high hereditary risk

Abstract

Among <i>BRCA</i>-negative breast cancer patients with high hereditary risk in China, 10.2% carried mutations in cancer associated susceptibility genes. <i>MUTYH</i> and <i>PTCH1</i> had relatively high mutation rates (2.9% and 1.8%). Multigene testing contributes to understand genetic background of <i>BRCA</i>-negative breast cancer patients with high hereditary risk.