Concepedia

Incidental Richter transformation in chronic lymphocytic leukemia patients during temporary interruption of ibrutinib

Paul J. Hampel, Hua‐Jay J. Cherng, Timothy G. Call, Wei Ding, Mahsa Khanlari, Ellen D. McPhail, Roberto N. Miranda, Pei Lin, Hussein A. Tawbi, Alessandra Ferrajoli,

Blood Advances · 2020 · 22 citations · 16 references

DOIFull text

Open access

Concepts

Abstract

Key Points An incidental histologic diagnosis of DLBCL was identified during temporary interruption of ibrutinib treatment in patients with CLL. In contrast to an aggressive clinical course typical of Richter transformation, these patients responded to reinitiation of ibrutinib alone.

References

16

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

Christine P. Hans · Blood · 2003 · 4.2K citations · Full text

iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL

Michael Hallek, Bruce D. Cheson, Daniel Catovsky et al. · Blood · 2018 · 1.6K citations · Full text

Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue

David W. Scott, George W. Wright, Paul Williams et al. · Blood · 2014 · 603 citations · Full text

Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia

Kami J. Maddocks, Amy S. Ruppert, Gerard Lozanski et al. · JAMA Oncology · 2015 · 568 citations · Full text

Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome

Ekaterina Chigrinova, Andrea Rinaldi, Ivo Kwee et al. · Blood · 2013 · 248 citations · Full text