SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, Hannah Kleine‐Weber, Simon Schroeder, +10

Cell

MedicineViral PathogenesisImmunologyIs BlockedVirology +6

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan, Yuanyuan Zhang, Yaning Li, +3

Science

Presumed Asymptomatic Carrier Transmission of COVID-19

Yan Bai, Yao Ling-sheng, Tao Wei, +4

JAMA

Virus EpidemiologyFamily MembersEmerging Infectious DiseasesPossible TransmissionCovid-19 Pandemic +10

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

Michael Letko, Andrea Marzi, Vincent J. Munster

Nature Microbiology

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Xiuyuan Ou, Yan Liu, Xiaobo Lei, +15

Nature Communications

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jérôme Hadjadj, Nader Yatim, Laura Barnabei, +27

Science

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

Muthiah Vaduganathan, Orly Vardeny, Thomas Michel, +3

New England Journal of Medicine

HypertensionCardiovascular DiseaseAntihypertensive TherapyVascular PharmacologyPharmacology +11

COVID-19 cytokine storm: the interplay between inflammation and coagulation

Ricardo J. José, Ari Manuel

The Lancet Respiratory Medicine

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

Ke Wang, Wei Chen, Zheng Zhang, +42

Signal Transduction and Targeted Therapy

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

Ilona Glowacka, Stephanie Bertram, Marcel A. Müller, +10

Journal of Virology

Membrane FusionProtease InhibitorsHumoral Immune ResponseBiochemistryReduces Viral Control +13