Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami

Robert E. Carraway, Susan E. Leeman · Journal of Biological Chemistry · 1973 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Structure of the agonist-bound neurotensin receptor

Jim F. White, Nicholas Noinaj, Yoko Shibata et al. · Nature · 2012 · 500 citations

Medicine, Neuroscience, Pharmacology +12

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds

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Pharmacy, Medicinal Chemistry, Pharmacology +16

Probing the activation-promoted structural rearrangements in preassembled receptor–G protein complexes

Céline Galès, Joost J J Van Durm, Stéphane Schaak et al. · Nature Structural & Molecular Biology · 2006 · 454 citations

Life Sciences, Biochemistry, Molecular Biology +12