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The efficacy and safety of remimazolam tosylate versus propofol in patients undergoing colonoscopy: a multicentered, randomized, positive-controlled, phase III clinical trial.

Shaohui Chen, Jin Wang, Xiaohan Xu, Yuguang Huang, Shanfu Xue, Anshi Wu, Xiaoju Jin, Qiang Wang, Jianrui Lyu, Sheng Wang,

PubMed · 2020 · 162 citations · 10 references

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Abstract

<0.001) were less frequent in remimazolam group compared with propofol group. In conclusion, remimazolam tosylate is non-inferior in sedation efficacy while safer than propofol in patients undergoing colonoscopy.

References

10

CNS 7056

Gavin J. Kilpatrick, Margaret McIntyre, Richard F. Cox et al. · Anesthesiology · 2007 · 399 citations · Full text

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A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056)

Laurie J. Antonik, D. Ronald Goldwater, Gavin J. Kilpatrick et al. · Anesthesia & Analgesia · 2011 · 369 citations

, , +17

Safety and Efficacy of Remimazolam Compared With Placebo and Midazolam for Moderate Sedation During Bronchoscopy

Nicholas J. Pastis, Lonny Yarmus, Frank Schippers et al. · CHEST Journal · 2018 · 314 citations

, , +7

A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and midazolam in patients undergoing colonoscopy

Douglas K. Rex, Raj Bhandari, Taddese Desta et al. · Gastrointestinal Endoscopy · 2018 · 304 citations · Full text

, , +6

A Phase IIa, Randomized, Double-Blind Study of Remimazolam (CNS 7056) Versus Midazolam for Sedation in Upper Gastrointestinal Endoscopy

Keith M. Borkett, Dennis Riff, Howard I. Schwartz et al. · Anesthesia & Analgesia · 2014 · 231 citations

, , +7