Bioactive Self‐Pumping Composite Wound Dressings with Micropore Array Modified Janus Membrane for Enhanced Diabetic Wound Healing

Abstract

Abstract Treatment of chronic wounds such as diabetic wounds with large volumes of biofluids is a significant clinical challenge due to ischemia caused by localized edema. To alleviate edema and stimulate angiogenesis, a four‐layer composite dressing is designed with a micropore array modified Janus membrane for self‐pumping and bioactive ion backflow, a superabsorbent layer for high capacity water absorption, and a bioactive layer containing bioglass for stimulating angiogenesis. The modified Janus membrane not only allows wound exudates transport from wound bed to the dressing, but also enables controlled backflow of bioactive ion containing fluid to the wound bed for stimulating angiogenesis. The in vivo experiment confirms the function of composite dressing in reducing wound edema, stimulating blood vessel formation and promoting diabetic wound healing. These results demonstrate that the novel composite dressing is a promising wound healing biomaterial for promoting chronic wound healing, and the unique characteristics of the micropore arrayed Janus membrane may extend its applications in biomedicine.