MicroRNAs in Atrial Fibrillation: Pathophysiological Aspects and Potential Biomarkers

Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia associated with increased morbidity and mortality. The pathophysiological mechanisms underlying the development of AF are not entirely clear. In addition, there are no optimal biomarkers for the early detection and prognosis for patients with AF. Emerging studies have uncovered a role for miRNAs in the initiation and maintenance of cardiovascular disease.This review discusses the role of miRNAs in the pathogenesis of AF as well as the possibility of using miRNAs as biomarkers for detecting and predicting AF. (