Palladium-Catalyzed Monoarylation of Arylhydrazines with Aryl Tosylates

Abstract

A palladium-catalyzed C-N bond coupling reaction between arylhydrazines and aryl tosylates for facile synthesis of unsymmetrical <i>N</i>,<i>N</i>-diarylhydrazines has been developed. Employing the catalyst system of Pd(TFA)₂ associated with newly developed phosphine ligand <b>L1</b>, the monoarylation of arylhydrazine proceeds smoothly to afford desired products in good-to-excellent yields (up to 95%) with good functional group compatibility. This method provides an alternative synthetic pathway for accessing structurally diversified <i>N</i>,<i>N</i>-diarylhydrazines from simple and easily accessible coupling components.