Prolonged Low-Dose Methylprednisolone in Patients With Severe COVID-19 Pneumonia

Abstract

In patients with severe COVID-19 pneumonia, early administration of prolonged MP treatment was associated with a significantly lower hazard of death (71%) and decreased ventilator dependence. Treatment was safe and did not impact viral clearance. A large randomized controlled trial (RECOVERY trial) has been performed that validates these findings. <b>Clinical trial registration. </b>ClinicalTrials.gov NCT04323592.