Remote sp² C–H Carboxylation via Catalytic 1,4-Ni Migration with CO₂

Abstract

A remote catalytic reductive sp2 C–H carboxylation of arenes with CO2 (1 bar) via 1,4-Ni migration is disclosed. This protocol constitutes the first catalytic 1,4-Ni migration reported to date, thus offering new vistas in the Ni-catalyzed reductive coupling arena while providing an unconventional new platform for incorporating electrophilic sites at remote sp2 C–H linkages.