Concepedia

LNK deficiency decreases obesity-induced insulin resistance by regulating GLUT4 through the PI3K-Akt-AS160 pathway in adipose tissue

Xiaozhu Zhong, Chuanfeng Ke, Zhaoxi Cai, Hao Wu, Yang Ye, Xiaolin Liang, Liqun Yu, Sushi Jiang, Jun Shen, Laiyou Wang,

Aging · 2020 · 22 citations · 21 references

DOI

Concepts

Abstract

adipose tissue showed activated reactivity for IRS1/PI3K/Akt/AS160 signaling, and administration of a PI3K inhibitor impaired glucose uptake. In conclusion, LNK plays a pivotal role in adipose glucose transport by regulating insulin-mediated IRS1/PI3K/Akt/AS160 signaling.

References

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