Publication | Closed Access
Tanshinone IIA synergistically enhances the antitumor activity of doxorubicin by interfering with the PI3K/AKT/mTOR pathway and inhibition of topoisomerase II: <i>in vitro</i> and molecular docking studies
88
Citations
18
References
2020
Year
Molecular BiologyPharmacotherapyDna IntercalatorsCardiovascular ToxicityTumor BiologyMolecular PharmacologyMedicinal ChemistryMolecular Docking StudiesAnti-cancer AgentTopoisomerase IiMechanism Of ActionCancer TreatmentPi3k/akt/mtor PathwayPharmacologyCell BiologyNatural SciencesPhysiologyTanshinone IiaMedicineSchematic DiagramDrug Discovery
Schematic diagram showing the pharmacophoric features of doxorubicin and tanshinone IIA as DNA intercalators, and their effects on cardiac tissues.
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