Concepedia

Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression

Shi‐Bin Li, Jeremy C. Borniger, Hiroshi Yamaguchi, Julien Hédou, Brice Gaudillière, Luı́s de Lecea

Science Advances · 2020 · 114 citations · 47 references

DOIFull text

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Concepts

Abstract

Activation of a neural circuit that triggers an acute stress response increases wakefulness and changes the immune landscape.

References

47

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text

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The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

Luı́s de Lecea, Thomas S. Kilduff, Christelle Peyron et al. · Proceedings of the National Academy of Sciences · 1998 · 3.9K citations

, , +15

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

Nathalie Auphan‐Anezin, Joseph A. DiDonato, Caridad Rosette et al. · Science · 1995 · 2.4K citations

, , +17

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

Sean C. Bendall, Erin F. Simonds, Peng Qiu et al. · Science · 2011 · 2.4K citations

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Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Junko Hara, Carsten T. Beuckmann, Tadahiro Nambu et al. · Neuron · 2001 · 1.4K citations · Full text

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