Effectiveness of copper nanoparticles loaded microsponges on drug release study, cytotoxicity and wound healing activity

Abstract

The aim of the study was to evaluate the green synthesized copper nanoparticles loaded microsponges for the better wound healing activity. Being an excellent antimicrobial and antioxidant agent, proven already, now the loaded microsponges also checked for its in- vitro drug release study in which it fits best into the korsemeyer-peppas kinetic model. It was subjected to cytotoxicity test against Vero cell lines using MTT assay. It showed IC50 value of 125 μg. Wound healing activity of this microsponge was analyzed through in-vitro scratch assay in which it possessed a potential wound healing property.