Concepedia

Publication | Open Access

The Apelin–Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis

DOIFull Paper Access

43

Citations

39

References

2020

Year

Lixian Chen, Tianhao Zhou, Tori White, April O’Brien, Sanjukta Chakraborty, Suthat Liangpunsakul, Zhihong Yang, Lindsey Kennedy, Romil Saxena, Chaodong Wu,
Hepatology

Abstract

The APLN-APJ axis induces cholangiocyte proliferation through Nox4/ROS/ERK-dependent signaling and HSC activation through intracellular ROS. Modulation of the APLN-APJ axis may be important for managing cholangiopathies.

References

YearCitations

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