Synthesis of CF₃-Substituted 1,6-Dihydropyridazines by Copper-Promoted Cascade Oxidation/Cyclization of Trifluoromethylated Homoallylic <i>N</i>-Acylhydrazines

Abstract

A highly efficient strategy for the construction of CF₃-substituted 1,6-dihydropyridazines has been developed by cascade oxidation/cyclization of trifluoromethylated <i>N</i>-acylhydrazines. The produced 1,6-dihydropyridazines could be easily transformed to 3-trifluoromethyl pyridazine derivatives. Some of the 1,6-dihydropyridazines exhibited aggregation-induced emission (AIE). DFT calculations were conducted to explain the mechanism.