Concepedia

Proton Magnetic Resonance Spectroscopy Lactate/N-Acetylaspartate Within 48 h Predicts Cell Death Following Varied Neuroprotective Interventions in a Piglet Model of Hypoxia–Ischemia With and Without Inflammation-Sensitization

Raymand Pang, Kathryn A. Martinello, Christopher Meehan, Adnan Avdic-Belltheus, Ingran Lingam, Magdalena Sokolska, Tatenda Mutshiya, Alan Bainbridge, Xavier Golay, Nicola J. Robertson

Frontiers in Neurology · 2020 · 24 citations · 41 references

DOIFull text

Open access

Concepts

Abstract

= 0.523). Overall, Lac/NAA correlated best with cell death and microglial activation. These data align with clinical studies demonstrating Lac/NAA superiority as an outcome predictor in neonatal encephalopathy (NE) and support its use in preclinical and clinical neuroprotection studies.

References

41

User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability

Paul A. Yushkevich, Joseph Piven, Heather C. Hazlett et al. · NeuroImage · 2006 · 9K citations

, , +16

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Luc Pellerin, Pierre J. Magistretti · Proceedings of the National Academy of Sciences · 1994 · 2.9K citations · Full text

, , +17

Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy

Seetha Shankaran, Abbot R. Laptook, Richard A. Ehrenkranz et al. · New England Journal of Medicine · 2005 · 2.8K citations · Full text

, , +14

Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes

Denis Azzopardi, Brenda Strohm, Neil Marlow et al. · New England Journal of Medicine · 2014 · 697 citations · Full text

, , +13

Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain

Daisuke Ito, Kortaro Tanaka, Shigeaki Suzuki et al. · Stroke · 2001 · 593 citations

, , +15