Concepedia

Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation

Wener Li, Michael Stauske, Xiaojing Luo, Stefan Wagner, Meike Vollrath, Carola S. Mehnert, Mario Schubert, Lukas Cyganek, Simin Chen, Sayed-Mohammad Hasheminasab,

Frontiers in Cell and Developmental Biology · 2020 · 37 citations · 38 references

DOIFull text

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Concepts

Abstract

in BrS-CMs and alleviated the arrhythmic activity, suggesting their therapeutic potential for BrS patients.

References

38

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

Jamie D. Kapplinger, David J. Tester, Mariëlle Alders et al. · Heart Rhythm · 2009 · 764 citations

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Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

Stefan Wagner, Nataliya Dybkova, Eva Rasenack et al. · Journal of Clinical Investigation · 2006 · 554 citations · Full text

, , +17

Transient outward current prominent in canine ventricular epicardium but not endocardium.

Silvio Litovsky, Charles Antzelevitch · Circulation Research · 1988 · 440 citations · Full text

, , +17

Ionic and Cellular Basis for the Predominance of the Brugada Syndrome Phenotype in Males

José M. Di Diego, Jonathan M. Cordeiro, Robert J. Goodrow et al. · Circulation · 2002 · 390 citations · Full text

, , +17

Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome

Koonlawee Nademanee, Hariharan Raju, Sofia V. de Noronha et al. · Journal of the American College of Cardiology · 2015 · 373 citations · Full text

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