An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish

Abstract

Collectively, these findings suggest negative modulation of zebrafish affective behavior by donepezil, support the key role of cholinergic mechanisms in behavioral regulation in zebrafish, and reinforce the growing utility of zebrafish models for studying complex behavioral processess and their neuroendocrine and neurochemical regulation.