Surface Plasmon resonance (SPR) provides an efficacious and label-free detection method for optical fiber bio-sensing. MoSe ₂ is one of the transition metal dichalcogenides (TMDCs) which has broad applications in detecting specific reactions. Cysteamine hydrochloride with enriched groups can generate self-assemble films for tight attachment. In this study we aimed to combine the rapid response of optical fiber SPR sensors with the enhanced sensitivity of MoSe ₂ nano-films. An optical fiber SPR biosensor with MoSe ₂ -Au nanostructure was proposed and implemented, and a sensitivity of 2821.81 nm/RIU was achieved, which was approximately 98.7% higher than that of conventional SPR sensor without using MoSe ₂ nanostructure. Furthermore, Bovine Serum Albumin (BSA) was utilized as the target molecule to test the bioaffinity of the biosensor with MoSe ₂ deposition cycles from 0 to 8. Weighing the sensitivity and the figure of merit (FOM), the best deposition cycle of MoSe ₂ was 4 with the sensitivity of 2793.36 nm/RIU and FOM of 37.24 RIU ^-1 . At last, immunization experiments were carried out using Goat-anti-Rabbit IgG and a detection limit of 0.33 μg/mL was achieved. The rapid response and the high bioaffinity showed a strong applicability of the proposed MoSe ₂ -Au SPR immune-sensor in specific interactions and immunization therapy.

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