Synthesis, characterization, antifungal and antibacterial activities evaluation of copper (II), zinc (II) and cadmium (II) chloride and bromide complexes with new (<i>E</i>)<i>‐</i>1‐(3,4‐dimethoxybenzylidene)‐4‐methylthiosemicarbazone ligand

Abstract

The reactions of Cu (II), Zn (II) and Cd (II) chloride or bromide with ( E ) ‐ 1‐(3,4‐dimethoxybenzylidene)‐4‐methylthiosemicarbazone (MTSVT) lead to the formation of new complexes. They were characterized by spectroscopic studies: IR, 1 H and 13 C NMR. The crystal structures of the compounds [MTSVT] ( L ), [ZnBr 2 (MTSVT) 2 ] ( 2 ), [CdCl 2 (MTSVT) 2 ] ( 3 ) and [CdBr 2 (MTSVT) 2 . H 2 O] ( 4 ) were determined by X‐ray diffraction. For complexes 2 – 4 , the ion is coordinated through the sulfur atom. All compounds were tested for their antifungal activity against human pathogenic fungi Candida albicans and Aspergillus fumigatus , and for their antibacterial activity against Gram (+) Bacillus subtilis and Enterococcus faecalis as well as against Gram (−) bacteria such as Paracoccus yeei and Acinetobacter baumanii. The results indicated that the metal complexes exhibited a marked enhancement in antibacterial activity compared with the parent Schiff base.