An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus–Related Lysosomal Abnormalities

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

Haeman Jang, David A. Boltz, Katharine Sturm‐Ramirez et al. · Proceedings of the National Academy of Sciences · 2009 · 461 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Xiaolai Zhou, Lirong Sun, Francisco Meirelles Bastos de Oliveira et al. · The Journal of Cell Biology · 2015 · 202 citations

Life Sciences, Cell Biology, Molecular Biology +17

Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia

Julie S. Snowden, Stuart Pickering‐Brown, Ian R. Mackenzie et al. · Brain · 2006 · 201 citations · Full text

Medicine, Genetics, Neurology +17

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis

Michael E. Ward, Robert Y. Chen, Hsin‐Yi Huang et al. · Science Translational Medicine · 2017 · 196 citations · Full text

Life Sciences, Genetics, Neurology +17

Portuguese family with the co-occurrence of frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis phenotypes due to progranulin gene mutation

Maria Rosário Almeida, Carmo Macário, Lina Ramos et al. · Neurobiology of Aging · 2016 · 127 citations

Life Sciences, Genetics, Neuroscience +11