Therapeutic iminoboronate-based polymersomes with a Cu(<scp>ii</scp>)-mediated Fenton reaction-enhanced ROS-response

Abstract

Reactive oxygen species (ROS)-responsive prodrug nanoplatforms may not work efficiently due to insufficient ROS concentrations, so therapeutic polymersomes of a metallisable triamine-centered iminoboronate-functionalized amphiphilic starlike prodrug (N₃-(OEG-IBCAPE)₄) are prepared to show a Cu(ii)-mediated Fenton reaction-enhanced ROS response.