Concepedia

Mitochondria-anchoring and AIE-active photosensitizer for self-monitored cholangiocarcinoma therapy

Tao Zhou, Jianfang Zhu, Dan Shang, Chuxing Chai, Youzhen Li, Haiying Sun, Yongqin Li, Meng Gao, Min Li

Materials Chemistry Frontiers · 2020 · 27 citations · 27 references

DOIFull text

Open access

Concepts

Abstract

An AIE-active photosensitizer, <bold>TTVPHE</bold>, can fast penetrate into cancer cells and efficiently trigger mitochondria-dependent apoptotic pathway with self-monitoring ability.

References

27

Mechanisms in photodynamic therapy: part one—photosensitizers, photochemistry and cellular localization

Ana P. Castaño, Tatiana N. Demidova, Michael R. Hamblin · Photodiagnosis and Photodynamic Therapy · 2004 · 2K citations

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Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study

Marianne Ortner, Karel Caca, Frieder Berr et al. · Gastroenterology · 2003 · 602 citations · Full text

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Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation

Dong Wang, Huifang Su, Ryan T. K. Kwok et al. · Chemical Science · 2018 · 447 citations · Full text

, , +17

Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

Wenjia Zhang, Xianglong Hu, Qi Shen et al. · Nature Communications · 2019 · 434 citations · Full text

, , +17

Far‐Red and Near‐IR AIE‐Active Fluorescent Organic Nanoprobes with Enhanced Tumor‐Targeting Efficacy: Shape‐Specific Effects

Andong Shao, Yongshu Xie, Shaojia Zhu et al. · Angewandte Chemie International Edition · 2015 · 400 citations · Full text

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