BTK Inhibition Impairs the Innate Response Against Fungal Infection in Patients With Chronic Lymphocytic Leukemia

Abstract

•BTK inhibition affects a productive immune response of CLL-associated macrophages (NLC) during <i>Aspergillus fumigatus</i> infection.•Reduction of TNF-α secretion and phagocytosis are detected in monocytes isolated from CLL patients during ibrutinib therapy.