A removable directing group-assisted Rh(<scp>iii</scp>)-catalyzed direct C–H bond activation/annulation cascade to synthesize highly fused isoquinolines

Abstract

A removable directing group-assisted Rh(<sc>iii</sc>)-catalyzed direct C–H bond activation/annulation cascade was developed to synthesize highly fused isoquinolines with good to excellent yields and a good functional group tolerance.