Development of Naringenin Nanocrystals for Enhanced Solubility and Bioavailability

Abstract

Naringenin is a flavonoid which has been used for its wide pharmacological action from ancient years including as antidiabetic agent. Naringenin is a lipophilic drug (BCS-II) and have low water solubility (1 in 1000), bioavailability (<25%) and have short half-life (t 1/2 =1.3 -2.2h).