Further evaluation of differential expression of keratoconus candidate genes in human corneas

Abstract

A strong correlation between RT-qPCR and earlier RNA-Seq data confirms the possible involvement of genes from collagen synthesis and the TGF-β, Hippo, and Wnt signaling pathways in KTCN etiology. Our data also revealed altered expression of several genes, such as <i>LOX</i>, <i>SPARC</i>, and <i>ZNF469</i>, in which single nucleotide variants have been frequently identified in KTCN. These findings further highlight the heterogeneous nature of KTCN.