Biochemical studies of toxic agents. 3. The isolation of 1- and 2-naphthylsulphuric acid and 1- and 2-naphthylglucuronide from the urine of rats dosed with 1- and 2-naphthol

Abstract

The determination ofthe so-called 'ethereal sulphate content' of urine is a simple analytical procedure, and there are many reports in the literature which show that the administration of phenols to experi- mental animals is followed by an increased excretion ofethereal sulphates in the urine. On the other hand, because of the difficulties which have usually been encountered, relatively few ethereal sulphates have been separated from urine. For many phenols, therefore, the belief that they are converted to arylsulphuric acids in the body is based solely on the observation that when administered to animals they give rise to an increase in the ethereal sulphate content of the urine.