Redox-Neutral Photocatalytic Radical Cascade Cyclization for the Synthesis of CH₂CN/CF₂COOEt/CF₃-Containing Benzo[4,5]imidazo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-One Derivatives

Abstract

A novel method for the synthesis of benzo[4,5]imidazo[2,1-<i>a</i>]isoquinolin derivatives via visible-light-induced radical cascade cyclization is described. By using <i>N</i>-methacryloyl-2-phenylbenzoimidazoles and diverse radical precursors, various benzo[4,5]imidazo[2,1-<i>a</i>]isoquinolin derivatives containing CH₂CN/CF₂COOEt/CF₃ can be formed in good to excellent yields under mild reaction conditions. This method exhibits good functional group tolerance and a wide range of substrate scope.