Circadian Rhythm of Motor Restlessness and Sensory Symptoms in the Idiopathic Restless Legs Syndrome

Abstract

An independent circadian factor modulates the intensity of RLS, which seems to peak on the falling phase of the core temperature cycle. Therefore, the diagnostic criteria that RLS occurs with rest and during the night have independent bases. Furthermore, RLS may be partially controlled by some process or substance whose level varies with the normal circadian rhythm.